In clinical work often encounter diabetic patients in the application of hypoglycemic drugs in the dilemma between not using drugs for fear of seriousness of the condition, further deterioration of blood glucose, using drugs and afraid of the formation of drug dependence. In the process of entanglement missed the best time for diabetes treatment, premature diabetes complications that should not have occurred, today this issue and we do an analysis. First, let’s look at the definition of drug dependence, drug dependence is divided into two kinds of mental dependence and physical dependence, mental dependence refers to the patient’s special thirst for a certain kind of drug, after taking a special psychological satisfaction; physical dependence refers to the repetition of many times to give the same kind of drug, so that its central nervous system has undergone some kind of physiological or biochemical changes, resulting in a drug addiction, that is to say, the need for a certain kind of drug continues to exist in the body, otherwise the drug will not be used for a certain purpose. That is to say, a certain kind of drug needs to be present in the body continuously, or else the drug addiction will go too far and produce withdrawal symptoms. Most sedative-hypnotics, anxiolytics, strong painkillers such as morphine, opium, dulcolax, codeine and other drugs will become addictive in the long term. Therefore, use these medications only for the shortest period of time they are needed. Drugs for the treatment of diabetes, whether oral drugs or insulin, do not produce both mental dependence and physical dependence on the body, and therefore do not belong to the drugs that produce dependence. Secondly, diabetes mellitus is a chronic disease, only part of the patients with insignificant blood glucose elevation can control their blood glucose at normal level only by controlling their diet and reasonable exercise, while most of the patients need hypoglycemic drugs or applying insulin treatment in order to reduce their blood glucose to normal level. If blindly worried about drug dependence, long-term elevation of blood glucose will damage blood vessels (including large blood vessels and microvessels) and nerves, leading to the emergence of cardiovascular and cerebrovascular diseases, diabetic nephropathy, retinopathy, peripheral neuropathy, diabetic foot gangrene and other chronic complications. Some patients are worried about the application of glucose-lowering drugs can not be discontinued, in fact, whether to stop using glucose-lowering drugs depends on the patient’s own pancreatic islet function recovery, not depending on whether to use the drug. Third, when we use a variety of oral drugs or even combined use of insulin intensive glucose-lowering treatment to make blood glucose drop to the ideal level, but instead of adjusting the glucose-lowering drugs, appropriate to reduce the type or dose of glucose-lowering drugs, maintenance therapy, so that blood glucose no longer rise. There are also some people who temporarily stop taking the medication completely (for an indeterminate period of time) due to the recovery of pancreatic islet function as a result of the drop in blood glucose, but they need to continue to cooperate with diet and exercise, or else their blood glucose will rise again. Blood glucose control has been good, the pancreatic islet function is relatively well preserved, often maintenance drugs can be reduced to the minimum dosage; blood glucose control is not good or not regular treatment for a longer period of time, the pancreatic islet function is gradually declining, and ultimately the pancreatic islet function is completely lost, the need to use a variety of drugs and even multiple injections of insulin in order to maintain the stability of blood glucose. This unsatisfactory state is not caused by medication, but is the result of lack of or inappropriate medication. There are also some patients who do not use drugs, adopt a lifestyle of strict diet control and excessive exercise to achieve the goal of controlling blood glucose, and some of them even produce severe malnutrition. Such a lifestyle not only makes it difficult to maintain normal blood glucose, but also affects the quality of life and induces the emergence of other diseases. Therefore, the use of drugs to maintain good glycemic control not only does not lead to drug dependence, but also reduces the incidence of diabetes-related complications and significantly improves the quality of life of patients.