There is no obvious evidence that clopidogrel hydrochloride tablets and methylcobalamin tablets can not be taken at the same time, if there is any discomfort after taking it, consult a doctor promptly. Clopidogrel hydrochloride tablets is a kind of clinically used antiplatelet drugs, which can achieve the effect of antiplatelet aggregation mainly by inhibiting the binding of adenosine diphosphate (ADP) and its platelet P2Y12 receptor, and the activation of glycoprotein GPIIb/IIIa complex. It is suitable for the prevention of atherosclerotic thrombosis, such as recent heart attack or acute coronary syndrome patients. Methylcobalamin Tablets, the main active ingredient of which is methylcobalamin, are commonly used in peripheral neuropathy. There is no interference between the pathways and effects of the two drugs, i.e., there is no interaction between the two drugs, so they can be taken at the same time. If there is an allergic reaction to one of the above drugs, or any discomfort after taking them at the same time, you should stop taking them together, and at the same time, you should go to the hospital in a timely manner to consult a doctor and adjust the way of medication. The specific use of medication should follow the doctor’s instructions.