Penile cancer is one of the tumors of male genital organs, which is diagnosed mainly through clinical manifestations and pathological section examination. Penile cancer usually occurs between 40 and 60 years old and starts from the head of penis and inner plate of foreskin, and clinical symptoms are generally typical. Early stage penile cancer can be manifested as hypertrophy of penile head or epithelium of foreskin, but it is not easy to be detected. Subsequently, papules, warts and cauliflower-like patches and ulcers appear on the head of penis, followed by erosion with hard and uneven edges, causing stinging or burning pain and purulent foul-smelling discharge. In the late stage, it can be cauliflower-like and penetrate from the prepuce. For patients with prepuce, because early stage penile cancer is deeply hidden in the deep surface of foreskin, it cannot be detected by naked eyes, but it can cause itchy and painful penis, and there is often purulent discharge from the front of penis. If carefully palpated through the foreskin, a lump or nodule can be touched and there is local tenderness. In advanced stage, the tumor will break through the cavernous fascia and foreskin and protrude outward, which is the typical manifestation of penile cancer. Based on the above typical manifestations, if lumps and ulcers with foul-smelling discharge are found on the head of the penis, and the edges of the ulcers are elevated, and if the ulcers do not heal over time and are expanding day by day, there is no difficulty in diagnosing penile cancer. For patients with prepuce or circumcision, if the suspected lump is touched through the foreskin, circumcision must be performed and the lump must be biopsied and pathologically examined at the same time to make a clear diagnosis.