Anal painkillers usually work within half an hour to two hours, and the medication works within 12-30 minutes after it is inserted into the anus. But before treatment, it is important to know what the cause is. Anal pain can be caused by fissures, hemorrhoids, etc. Fissures can cause the anal skin to tear due to the dryness of the bowels, resulting in severe pain and blood. The pain will last for some time, and hemorrhoids will present with enlarged hemorrhoidal nuclei, bleeding, as well as pain, both of which need to be treated in a timely manner. Hemorrhoids, in particular, can be treated with pain relief by using a Ma Yinglong hemorrhoidal suppository inserted into the anus. Regardless of the type of pain medication, the general efficacy of the medication is within 2 hours. Because in this time, the organism will completely absorb the drug, and the medicine can be fully realized.