The peeling of skin on the hands of a 12-year-old girl may be caused by exfoliative keratolysis, contact dermatitis, fungal infections, etc., and should be treated according to the specific disease. 1. Exfoliative Keratolysis: the cause is complex, mainly in the daily care, such as eating more fresh fruits and vegetables, increase the intake of vitamins, to ensure that the skin’s nutritional supply; less contact with excessively hot or cold water or irritating liquids, to keep the palms of the hands dry and clean. 2. Contact dermatitis: For patients with contact dermatitis, they should avoid contact with irritating objects and use hydrocortisone cream and other medications as prescribed by the doctor to alleviate the symptoms of peeling skin. 3. Fungal infections: fungal infections, in addition to general daily care, but also need to follow the doctor’s instructions to use miconazole cream and other antifungal drugs. 12-year-old girl hands peeling, there may be other reasons, it is recommended to go to the hospital in time to improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.