For a long time, non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used in the treatment of various rheumatic diseases and cardiovascular diseases, such as aspirin, acetaminophen, indomethacin, diclofenac, ibuprofen, and nimesulide. Like any other drugs, NSAIDs can produce harmful reactions that are not related to the purpose of the drug, i.e. adverse drug reactions, while exerting therapeutic effects. Let’s learn more about NSAIDs-related gastric diseases! What are the clinical manifestations of non-steroidal anti-inflammatory drugs (NSAIDs)-associated gastroparesis? The clinical manifestations of the disease are dyspepsia, abdominal distension and pain, ulceration, bleeding, perforation, and anemia. The endoscopic features are diffuse gastric mucosal congestion and edema and multiple erosions and ulcers. Risk factors for NSAIDs-associated gastric disease: ① long-term, high-dose use of multiple NSAIDs ② advanced age (age > 60 years) ③ gender (higher in men than women) ④ heavy smoking and alcohol consumption ⑤ previous history of gastrointestinal ulcers, bleeding or perforation, hepatic and renal insufficiency, cardiovascular system diseases ⑥ H. pylori infection ⑦ association with glucocorticoids (cortisone, prednisone, methylprednisolone, dexamethasone, etc.) Please note that the incidence of this disease is greatly increased when multiple risk factors mentioned above are present at the same time! What are the precautions for taking non-steroidal anti-inflammatory drugs (NSAIDs)? ①Take the drugs under the guidance of a professional physician, and consult a physician to decide whether to continue using the drugs if there are suspected adverse reactions during the course of use ②Eat a light diet, avoid eating cold, spicy, oily products, and stop smoking and limiting alcohol ③If accompanied by H. pylori infection, eradication of H. pylori can alleviate the local inflammatory response and reduce the risk ④Regular electronic gastroscopy and e-colonoscopy can detect gastrointestinal ulcers in a timely manner and treat them In conclusion, only when physicians, patients and society pay attention to the issue of safe drug use together, adhere to the rational use of drugs, and try to avoid and reduce the harm of adverse drug reactions, a barrier of safe drug use can be truly built.