High total bilirubin may be related to liver disease, bile duct obstruction, hemolytic anemia, etc. Symptoms can be relieved by medication, endoscopic removal of stones, and treatment of primary disease. 1. Liver disease: If you suffer from hepatitis, cirrhosis and other liver diseases, it may lead to necrosis of liver cells and cause bilirubin degradation abnormality, and total bilirubin is high. Thiopronin enteric-coated tablets, lamivudine tablets and other drugs can be taken to protect the liver, antiviral treatment to alleviate the symptoms. 2. Bile duct obstruction: Bile duct stones can cause bile duct obstruction and lead to abnormal bilirubin excretion, resulting in high total bilirubin. Endoscopic removal of stones can be used to remove the stones and unblock the bile ducts, thus improving the phenomenon of high total bilirubin. 3. Hemolytic anemia: When hemolytic disease occurs, increased destruction of red blood cells will lead to high total bilirubin. The cause of hemolytic anemia should be searched for, and the primary disease should be treated actively to improve the symptoms. It is recommended that the patient go to the hospital in time to consult the doctor, after clarifying the cause of the disease, the correct treatment, the specific drugs need to be used under the guidance of the doctor.