It is generally believed that mesalazine suppositories are not fully absorbed until at least ten minutes after they are inserted. Mesalazine suppositories are mainly used for the treatment of ulcerative colitis, proctitis, Crohn’s disease and other diseases. Before using the suppository, you should go to defecation and insert the suppository through the anus with a PE hygienic finger cuff until it meets with a slight momentary loss of resistance. Mesalazine suppositories inserted will be dissolved and absorbed in the rectum, the time is not necessarily, mainly according to the individual situation. However, if it comes out within ten minutes, another dose should be re-inserted, because the outflow of the drug in the intestinal tract is too short to be fully absorbed, and it should stay at least ten minutes for the drug to be fully absorbed. Adverse reactions such as diarrhea, nausea, abdominal discomfort, headache, vomiting and skin rashes such as hives and eczema may occur with the use of this product. It is contraindicated in cases of hypersensitivity to mesalazine, salicylates and excipients; in cases of severe hepatic or renal impairment; and in children under 2 years of age. It is important to note that this product should be used with caution in patients who are pregnant or breastfeeding, and only if the prescribing physician judges that the benefits outweigh the risks. The drug should be applied under medical supervision.