In recent years, the use of non-invasive procedures (BOTOX injections, laser dermabrasion, soft tissue injections, etc.) has increased significantly in proportion to the growth of facial wrinkle reduction, and these trends have driven the study of facial anatomy. Whereas the face does not age as a homogeneous whole during the aging process, it is divided into multiple dynamic regions, and the study of these subcutaneous tissue compartments can guide the implementation and advancement of various non-invasive procedures for facial wrinkle reduction and facial rejuvenation. The following are the authors’ results based on a review and study of the relevant literature. Results: The forehead: divided into three fatty areas, with the central area located in the midline and extending into the dorsal nasal area, the border of which reaches what is known as the “central temporal septum”. The lateral temporal fat area is adjacent to the superior temporal septum and converges with the lateral subcutaneous buccal fat contact. Upper and lower eyelids: the intraorbital fat region, first thought to have two fat subdivisions in the upper part and three in the lower part, was later found to have three fat subdivisions in the upper eyelid after various studies, although the third fat subdivision sometimes adheres to the middle fat subdivision, and the degree of separation of the two regions was found to vary from person to person in cadaveric studies, but was histologically recognized as two regions. The subcutaneous tissue of the periorbital region: the upper region border reaches the orbicularis support ligament (ORL) and extends to the inner and outer canthus on both sides; the lower region is bordered superiorly by the insertion of the septum of the eye frame into the lid portion of the eyelid and inferiorly by the orbicularis support ligament, which arcs along the outer orbital rim and is further defined by the inner and outer canthus on both sides. The lateral region runs superiorly to the inferior temporal septum and inferiorly to the superior buccal septum. Superficial buccal region: Early studies suggested four fatty regions here: nasolabial, medial, central, and lateral temporal regions. The nasolabial region is bordered on one side by the nasolabial midline fold and on the upper border by the ORL, with the zygomaticus major also bordering this region. The medial zone is located next to the nasolabial zone mentioned above and borders the subcutaneous orbital region from the upper to the ORL and the lower to the mandibular fat area. The central zone is located next to the medial zone, above the parotid gland, and extends laterally to what is called the “lateral cheek septum”, which also borders the zygomaticus major muscle and forms the zygomatic arch ligament. The lateral temporal region is located most laterally, also above the parotid gland, and connects the lateral region of the forehead to the subcutaneous cervical fat region. Deep cheek: This area is located between the buccal fat pad and the zygomaticus major muscle, with the pear-shaped ligament of the nasal floor on one side and the ORL on the other, at a depth comparable to that of the orbicularis oculi. Further studies have shown that this area can also be considered as two separate parts: one adjacent to the pear-shaped septum and the other enclosing the levator muscle and adjacent to the buccal fat pad. Periorbital region: It is divided into two regions, one deep fat region for the upper and lower lips and one deep to the orbicularis oris muscle. The orbicularis oris muscle is inserted into the dermis at the border of the red lip tissue, and the fat area is inserted slightly shallower than this. Mandible: divided into two mandibular fat areas, with the mandibular inferior labial fold as the middle border. The lower border is the mandibular septum, which is where the mandible fuses with the broad neck muscle. Chin: a region of deep fat, deep to the chin muscle, with the lower lip as the border. It is clearly divided into two non-confluent areas on the left and right, which are distinguished from the perioral fat area. Discussion: With increasing age, the face also keeps aging in a more specific, but still relevant, way relative to the body. Changes in facial aging are reflected in bone structure, fat volume, ligament strength, skin characteristics, and vascular distribution. Various studies on aging have emphasized the importance of adipose tissue. Knowledge about the subcutaneous and superficial structures of the face has not been well used in various non-invasive facial rejuvenation procedures. Lasers, chemical peels, and injections are widely used all over the face or for problems such as wrinkles and hyperpigmentation that are visible to the naked eye. A study on lip augmentation by injection showed that without knowledge of fat partitioning, undesirable results called “overfilling” can occur. Currently, fillers are injected vertically into the skin junction of the red lips, deep into the superficial fat area of the lips, above the orbicularis oris muscle. According to research, if the injection site is further down into the deeper lip area, reaching the orbicularis oris muscle, it will not produce an “overfilled” appearance and will allow for a slight lip ectropion and a more pronounced red lip skin junction, resulting in a more youthful lip appearance. Another example is that when the salt solution is injected into the deep central fat area rather than the superficial nasolabial fold area, many changes occur, such as a fuller midface area, smoother tear troughs and nasolabial folds, and improved appearance of the cheekbone area. However, a common lack in many related studies is the lack of longitudinal studies, which will require further additional research in the future. In conclusion, facial aging is not only associated with superficial fat areas, but with all subcutaneous fat areas at the anatomical level. CONCLUSION: The authors propose the new concept that a better understanding of facial fat partitions can lead to new injection methods. These facial fat partitions can be used as a GPS (navigator) for facial injectable fillers.