Cardia xanthomas are verrucous proliferative lesions that appear in the cardia location, also known as gastric xanthomas. Cardia xanthomas are lesions caused by localized lipid metabolism disorders in the gastric mucosa, referring to the formation of verrucous hyperplasia by focal aggregation of macrophages that phagocytose lipids in the gastric mucosa. The etiology of cardia maculoma is still unclear, and it is generally believed that it may be associated with chronic inflammatory stimulation, primary hyperlipidemia, secondary hyperlipidemia, diabetes mellitus, and Helicobacter pylori infection. It is a high-risk factor for the development of gastric cancer and should be removed as early as possible in a timely manner. Timely detection and treatment usually have a good prognosis. Most patients can be removed at once by gastroscopic biopsy, while larger diameter tumors can be removed by parts and times. It is recommended that patients with cardia macular tumor should go to regular hospitals and listen to the advice of professional hospitals.