Pre-pregnancy checkups can be done in the eugenics counseling department, prenatal checkup department, or gynecology department. Before pregnancy, women should be prepared for contraception, and should take health checkups and eugenics checkups in advance, such as liver and kidney function checkups, blood glucose, blood lipid checkups, eugenics four checkups, blood routine, blood type checkups, and folic acid bioavailability checkups, etc. Women should take oral folic acid 3 months in advance according to the results of folic acid bioavailability checkups to prevent fetal neurological problems. Women should take oral folic acid 3 months in advance according to the results of folic acid bioavailability test to prevent the occurrence of fetal neural tube malformation. Before pregnancy, the man should also undergo a relative physical examination, including liver and kidney function tests, eugenics tests, and even routine semen tests. In 3 months in advance to quit smoking, banning alcohol, exercise to make the body in the best state, ready to prepare for pregnancy.