Lymphoma may cause shoulder pain in early stage. Lymphoma is a kind of malignant tumor originated from the blood system. Most patients in the early stage develop painless lumps in the neck, clavicle and other places, and they will keep growing with the aggravation of the disease, and they seldom have shoulder pain. Only a small number of patients, the tumor on the shoulder nerve, bone and other damage, may appear shoulder pain. If shoulder pain exists for a long time, as well as emaciation and fever, it is necessary to carry out X-ray and CT examination in time in order to confirm the diagnosis of lymphoma and take targeted treatment according to the situation; if it is only simple shoulder pain, it may be frozen shoulder, cervical spondylosis, and so on.