Stomach discomfort during quadruple therapy treatment can be relieved by adjusting the order of medication, adding gastric mucosa-protecting preparations such as magnesium aluminum carbonate, and strengthening physical fitness. 1. Adjust the order of medication: take proton pump inhibitors and bismuth before meal 0.5h, and take antibiotics after meal 1~2h to reduce the stimulation of antibiotics to the stomach and intestines. 2. Add gastric mucosa protection preparations: such as magnesium aluminum carbonate, to protect the gastric mucosa and reduce the discomfort caused by antibiotics. 3. Enhance physical fitness: regular work and rest, adequate rest, eat more fresh vegetables and fruits, supplement high-quality protein, eat a light diet, low-salt, less pickled and fried food. Quit smoking and drinking to minimize damage to stomach function and promote recovery. It is worth noting that: try not to stop the four drugs after the start of treatment, if the above measures can not improve the patient’s gastric symptoms, you can communicate with the attending physician to decide whether to add other drugs, or terminate the treatment program, the alternative treatment program at a later date. The above medications should be used in accordance with the doctor’s instructions.