Taking enalapril in the morning and hydrochlorothiazide at night is fine, but it is recommended that both drugs be taken orally in the morning. Enalapril mainly acts on angiotensin-converting enzyme, which has the effect of lowering blood pressure, and at the same time can be used in the treatment of patients with heart failure. Adverse reactions such as nausea and palpitations may occur after use, and this drug should not be used in patients with renal artery stenosis and liver failure. Hydrochlorothiazide belongs to diuretics, can reduce the load on the heart, suitable for the treatment of patients with heart failure with edema, can be combined with enalapril at the same time for the treatment of heart failure. Adverse reactions such as dry mouth and skin rash may occur after use, and its contraindications are not clear. Enalapril and hydrochlorothiazide can be taken at any time throughout the day, but it is recommended that hydrochlorothiazide be taken in the morning, and taking it at night may lead to an increase in nighttime urination, which is not conducive to the patient’s rest, and may even lead to aggravation of the condition. The combination of enalapril and hydrochlorothiazide is a good match, and the specific way of using the drug should follow the doctor’s instructions.