Meijer syndrome is also known as blepharospasm-oral and mandibular dystonia, and is diagnosed mainly by clinical symptoms, while laboratory tests and imaging tests can play a role in differential diagnosis. 1. Clinical symptoms: The diagnosis of Meijer syndrome is mainly based on the clinical symptoms caused by the disease, which will lead to the patient’s bilateral eyelid involuntary closure, accompanied by symmetrical irregular contraction of the facial muscles. 2. Laboratory tests: Laboratory tests mainly check trace elements, blood electrolytes and biochemical tests, which can play a role in differential diagnosis. 3. Imaging examination: Imaging examination is one of the measures for differential diagnosis, which mainly includes head CT, MRI, magnetic resonance angiography, cervical vascular ultrasound, cardiac ultrasound, etc. Patients with Meijer’s syndrome usually do not have characteristic imaging changes. If symptoms suspected to be Meijer syndrome appear, it is recommended to consult a doctor in time and be evaluated by a professional doctor. There is no cure for Meijer syndrome yet, but one should intervene as early as possible once the diagnosis is confirmed as a way to improve the quality of survival.