The effect of biological agents in the treatment of rheumatoid arthritis is relatively certain and has been widely used in clinical practice in recent years, which can play the role of rapid anti-inflammation, pain relief and swelling reduction, and the long-term effect is also good, with the effect of anti-inflammation and prevention of bone destruction. In addition, its adverse reactions are relatively mild, mainly local rash at the injection site, and some patients who use it for a long time may cause easy infection, especially tuberculosis infection, and may also lead to an increase in the prevalence of lymphatic system tumors. On the other hand, biological agents are more expensive, so many patients have difficulty in adhering to regular clinical application, but overall the effectiveness is still relatively good.