Low creatinine, generally no special symptoms and manifestations, mainly for the primary disease manifestations caused by creatinine reduction, low creatinine is common in progressive muscular atrophy, leukemia, anemia, liver dysfunction and other diseases, but also seen in normal people. 1. Progressive myasthenia gravis: manifested as progressive atrophy of muscles all over the body, patients may be accompanied by fatigue, reduced muscle strength, wasting, malnutrition and other manifestations. 2. Leukemia: patients have fatigue, anemia, fever, bleeding, enlarged liver and spleen lymph nodes. 3. Anemia: mainly manifested by pale skin and mucous membrane, weakness, dizziness, headache, tinnitus, fatigue, memory loss and other manifestations. 4. Liver dysfunction: patients may have weakness, jaundice, pain in liver area and other manifestations. There is no special performance of blood creatinine reduction, mainly based on the performance of the original disease, if long-term creatinine is low, it is recommended that the patient further consult the doctor for clarification.