Callus on the soles of the feet refers to callus in medicine, which may be removed through medication, physical therapy and other ways. 1. medication: patients with callus can follow the doctor’s instructions for external use of exfoliators, such as salicylic acid ointment, retinoic acid cream, etc., can make the keratin soften, fall off, so as to remove callus. 2. Physical therapy: patients can also choose cryotherapy, the use of liquid nitrogen freezing way to destroy the local skin, so as to make the callus off. You can also choose carbon dioxide laser treatment, the use of laser photothermal effect on the local lesion tissue, to remove the callus. More ways to remove callus, it is recommended to go to the regular hospital, under the guidance of the doctor to choose the appropriate way to remove.