The changes that may occur after quitting smoking with emphysema pemphigoid include: relief of related symptoms, delayed disease progression, and decreased risk of lung cancer and cardiovascular disease. 1. Relief of symptoms: Smoking will stimulate the bronchial mucosal epithelium to secrete a large amount of mucus, but also damage the airway epithelium and cilia, reducing the self-purifying ability of the airways, which in turn causes sputum to be difficult to cough up to form sputum plugs blocking the bronchial tubes, causing chest tightness, asthma, coughing up sputum and other symptoms, after quitting smoking, bronchial secretion of mucus is reduced, the self-purifying ability of the airways is restored, and the patient’s related symptoms will be relieved effectively, significantly improving the quality of life. 2. Delayed disease progression: long-term smoking will seriously damage lung tissue and lead to the development of emphysema and pulmonary blisters; quitting smoking can effectively delay the progression of the disease, reduce the risk of pneumothorax, chronic pulmonary heart disease and other complications, and effectively prolong the survival period. 3. Reduce the risk of related diseases: quitting smoking can effectively reduce the risk of lung cancer, coronary heart disease, cerebral hemorrhage and other diseases. Smoking has serious damage to many systems of the whole body, it is recommended to quit smoking as soon as possible to reduce the risk of related diseases.