Radiotherapy can be done after surgery for tongue cancer highly differentiated squamous cell carcinoma, which can consolidate the treatment and reduce the chance of recurrence and metastasis. Tongue cancer high differentiated squamous cell carcinoma is a malignant tumor of oral cavity, which usually manifests as unclear border of tongue and non-smooth surface, and usually the swelling is fragile and easy to bleed. Early stage patients do not need radiotherapy after surgery if there are no other risk factors, and regular review is enough. If it is middle or late stage patients or risk factors such as peripheral lymph node metastasis, radiotherapy can be used to control the spread of cancer cells and alleviate the condition. Radiotherapy for highly differentiated squamous cell carcinoma of tongue can inhibit and kill cancer cells, control the condition, shrink the tumor, improve the symptoms and prolong the survival time, the specific situation needs to be analyzed according to the patient’s physical condition and clinical symptoms. Patients with highly differentiated squamous cell carcinoma of tongue are very weak during the treatment period, so they need to strengthen nutritional conditioning, and can drink some soups, such as bone broth, crucian carp broth, turtle broth, etc. They need to pay attention to hygiene and care during radiotherapy, keep a good mindset, and don’t have too much psychological pressure.