There is no so-called best treatment for cirrhosis ascites, it needs to be combined with the cause and symptoms, according to the specific condition to take the first-line, second-line, third-line comprehensive treatment measures, such as the use of diuretics, ascites, etc., if necessary, liver transplantation treatment, treatment of medication in accordance with the doctor’s orders. 1. First-line treatment: including etiological treatment, actively correcting the causes of cirrhosis, such as viral hepatitis, alcoholic hepatitis, etc., reasonably restricting salt intake, commonly used drugs include diuretics, such as spironolactone, furosemide, etc., and at the same time, avoiding hepatotoxic drugs. 2. Second-line treatment: rational use of vasoconstrictor-activated drugs and certain diuretics, such as terlipressin, tolvaptan, etc., ascites can be put on ascites treatment, pay attention to the need for timely supplementation of albumin, also feasible jugular intrahepatic portacaval shunt, and at the same time, discontinue the use of non-steroidal anti-inflammatory drugs and vasodilator-activated drugs. 3. Third-line treatment: mainly include liver transplantation, ascites concentration reflux or renal replacement therapy, as well as peritoneal α-drainage pump or peritoneal venous shunt, etc., pay attention to the adverse reactions and complications. Cirrhosis ascites, it is recommended that timely consultation, under the guidance of the doctor for targeted treatment.