The chemical name of collagenase is Collagenase, which can specifically hydrolyze the three-dimensional helix structure of natural collagen under physiological pH and temperature conditions and degrade it into amino acid-like substances that can be absorbed by the body without damaging other proteins and tissues. Since the main components of the nucleus pulposus are mucopolysaccharide and collagen, Carl Hirsch, a Swedish scholar, proposed in 1959 to inject some enzyme into the disc to accelerate the degenerative process of the disc and reduce the pressure on the nerve roots by making it fibrotic and small. Mechanism of action: The main component of the intervertebral disc is collagen, and collagenase has a specific lysis effect on it. Under CT or digital X-ray fluoroscopy, the collagenase drug is injected into the herniated disc or outside the disc to dissolve and absorb the herniated disc without damaging blood vessels, nerves, bones and muscle tissue. Thus, the compression on the nerve root is released and the treatment purpose is achieved. Advantages: Compared with open surgery, collagenase discolysis has the following advantages: 1. Can achieve the purpose of radical treatment: collagenase has specific solubility, which can dissolve the herniated disc tissue, release the compression on the nerve root and eliminate the inflammation that causes pain. 2, high safety: under the X-ray fluoroscopy or CT monitoring, the expert operation can avoid the nerve, blood vessels and other important structures, accurate access to the injection site. 3, not easy to recur: the prominent nucleus pulposus is dissolved and absorbed, after surgery, pay attention to rest and rehabilitation exercises, not easy to recur. 4.Little damage: the surgical incision is only the size of a needle eye, which can heal quickly. No damage to the bone and ligament, maintaining the original structure of the human body, can keep the spine stable. 5.Less pain: operated under local anesthesia, almost no pain. 6.Short hospitalization time: The doctor will suggest the length of stay after the operation according to the patient’s condition. 7, low cost: only about 40% of open surgery, reducing the economic burden of patients. Indications for collagenase chemical discolysis: lumbar disc herniation, invalidated by regular non-surgical treatment for 6 months; recurrent symptoms; sudden lumbar disc herniation; lumbar disc herniation combined with loss of nerve root function or cauda equina nerve dysfunction. Warm tip: Those with cauda equina syndrome, those with lumbar spine slippage, those with protrusion greater than 10mm, and those with allergy are not suitable for this therapy.