Melanoma is a common clinical tumor disease that occurs more often in middle-aged and elderly people, more often in men than in women. The appearance of this disease can cause serious impact on the health of patients, and without timely treatment directly endanger life, so suffering from this disease, it should be diagnosed in a timely manner. Melanoma is not the need for pathological examination, it is worth to know its examination methods. The examination methods of melanoma 1, pathological examination: This is a reliable way to check melanoma and is also the main method of differential diagnosis. When the clinical conditions allow, suspicious lesions should be excised including the entire thickness of the tumor and the infiltrated tissues in all layers of the skin, and biopsy should be performed to obtain pathological diagnosis. Needle aspiration, scraping, clamping, cutting or chiseling to take sample biopsy should not be avoided to prevent the spread of lesions. 2.Electron microscopy: This is one of the tests to be performed for melanoma patients. Through this method, the melanosomes of malignant melanoma at different stages of development can be observed, which are characteristic and can be identified with other tumor cells and phagocytic melanocytes, and immunoenzymatic labeling (S-100), monoclonal anti-HMB-45 and flow cytometric DNA analysis can be observed, which has diagnostic value for confirming the diagnosis of malignant melanoma. 3.X-ray examination: X-ray examination can check for possible, asymptomatic lung metastases. If it suggests metastasis, it should be confirmed by lung tomography or CT scan. 4.Serum alkaline phosphatase or lactate dehydrogenase measurement: This approach can be effective for the assessment of liver involvement, or those with increased or symptoms such as weight loss, anorexia and upper abdominal pain should undergo liver ultrasound and abdominal CT scan.