Sacubitril valsartan sodium tablets are recommended to be taken with food or on an empty stomach. Sacubitril valsartan sodium tablets are a combination preparation made from sacubitril and valsartan and are indicated for the treatment of chronic heart failure in adults with reduced left ventricular ejection fraction of ≤40%, NYHA class II-IV, and essential hypertension. Adverse effects of the drug include renal impairment, hyperkalemia, angioedema, and hypotension. The drug is generally recommended to be taken with food or on an empty stomach. Caution needs to be contraindicated in persons who are hypersensitive to the product, in persons with moderate to late pregnancy, in the presence of a history of angioedema previously associated with treatment with angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists, in patients with hereditary or idiopathic angioedema, in persons with biliary cirrhosis and cholestasis, and in persons with severe hepatic impairment. Specific medication should be administered under the guidance of a specialist.