Both minor and major triplets are very common diseases, especially major triplets, which have a very large number of patients in China. There are many patients who will make certain comparisons between Xiaosangyang and Daosangyang, they will want to know which is more serious, and also want to know exactly what are the differences between Xiaosangyang and Daosangyang.
A. Comparison of the conditions of small and large triplets
People generally divide small triplets of hepatitis B into three categories, with some types not requiring treatment and others requiring immediate treatment. If the DNA test is negative for minor tri-positive and liver function and ultrasound are normal for a long time, it means that the virus is no longer replicating and is not contagious, so there is no need for isolation and treatment. This condition accounts for about 60% – 70% of the total number of patients with small triplets, and there is no further treatment available at home or abroad.
There is also a situation in which the hepatitis B virus DNA replicates at a low level, PCR test is <106, liver function is normal or mildly abnormal, and the spleen is slightly thicker on abdominal ultrasound, which is called the chronic hepatitis B virus residual stage. This condition accounts for about 20% of the total number of patients with small triplets.
There is an extremely severe type of hepatitis B minor triple-positive patients, and this type has the greatest severity. It is the type with a high level of hepatitis B virus DNA replication (PCR test >106) and abnormal liver function, called “e antigen-negative chronic hepatitis B”.
This condition accounts for about 10% of the total number of patients with minor triplets, and is characterized by active viral replication and high infectivity, due to the mutation of the hepatitis B virus. This kind of major triplet is more serious when compared with minor triplet, which has a higher chance of transforming into cirrhosis and liver cancer.
Second, the definition of major and minor triplets is different
In the hepatitis B two-to-one test, hepatitis B surface antigen (HBSAg), hepatitis B surface antibody (HBsAb), hepatitis B e antigen (HBeAg), hepatitis B e antibody (HBeAb) and hepatitis B core antibody (HBcAb), of which 1, 3 and 5 are positive, are major triplets, and 1, 4 and 5 are positive for minor triplets.
Third, the symptoms of major and minor triple-positive are different
Major triple yang: usually no obvious symptoms, only a few people have discomfort in the liver area (under the right side of the chest, rib-covered area), vague pain, weakness, loss of appetite, nausea and aversion to oil, diarrhea, yellow face and urine, etc.
Small triple yang: the main symptoms are nausea, anorexia, fatigue, fever, “three yellow” (skin, sclera, urine yellow) characteristics and other symptoms.
Four, major and minor triple yang infectiousness is different
Generally speaking, major triple yang is more contagious than minor triple yang, because major triple yang is positive for hepatitis B e antigen, which means that the hepatitis B virus is actively replicating, so it is also more contagious. In contrast, small triplets are the opposite of large triplets in existence.
V. Differences in hepatitis B virus DNA test results
Major triple-positive: the patient has more positive HBV-DNA, indicating that there is a lot of virus in the body, strong replication and high infectivity.
Small triple-positive: the patient has more negative HBV-DNA, indicating that the virus in the body is less, but the amount of virus in the body of a small triple-positive patient is not necessarily less than that of a large triple-positive patient
The severity of hepatitis B cannot be judged solely on the basis of major or minor triplets, but should be judged on the basis of liver function, ultrasound, HBV-DNA and other detailed test results. The large triplet is not necessarily more dangerous than the small triplet, and conversely the small triplet is not necessarily safer than the large triplet.
Six, alert: large three yang poisonous, small three yang sinister
The big three yang is highly contagious, replicative and high viral volume so it is valued. While small triplets are often neglected due to their small infectiousness, also including patients have a sense of relief, but late stage liver disease instead is not easily detected, resulting in more serious consequences than large triplets. Therefore, the large and small triplets should be treated equally, always pay attention to themselves, seize the opportunity to actively treat.
The specific situation should go to the regular liver disease hospital for detailed examination, according to the results of reasonable analysis of the disease, to determine the viral replication, and treatment measures.