The clinical manifestations of acute leukemia include anemia, fever, bleeding, pain and other symptoms. 1. Anemia: patients with acute leukemia may be accompanied by anemia at the same time, even severe anemia. 2. Fever: patients with acute leukemia usually have fever, and if there is secondary infection, they may have high fever. 3. Bleeding: Nearly half of the patients will have bleeding in the early stage, and common bleeding includes skin bruises, nosebleeds, gum bleeds and so on. 4. Pain: Acute leukemia often has localized pressure pain in the lower part of the sternum, and may also have joint pain, bone pain, headache and other pain symptoms. Acute leukemia may also have other symptoms such as vomiting. Once you find that your body has the above discomforts, you should go to the hospital in time to find out the cause and get treatment under the doctor’s guidance.