Pimples on the flanks of the nose that hurt when pressed are often considered boils and acne, and require further differential diagnosis by a doctor. 1. Boils: Acute suppurative lesions that occur locally in the hair follicles of the flanks of the nose as a result of the invasion of individual hair follicles and their surrounding tissues by pathogenic bacteria such as Staphylococcus aureus, which can be painful when pressed. 2. Acne: Higher levels of androgens, Propionibacterium acnes proliferates and other causes can cause inflammatory reactions on the flanks of the nose, inflammatory papules can appear, and can appear at the same time when pressed on the situation of pain. It is recommended that people with acne on the flanks of the nose that hurts when pressed go to a regular hospital in a timely manner to clarify the cause of the disease and standardize the treatment under the guidance of the doctor to avoid delaying the condition.