Rheumatoid nodules are the more common extra-articular manifestation of rheumatoid arthritis and are a more typical symptom of rheumatoid arthritis. Patients with rheumatoid nodules tend to be positive for rheumatoid factor and have an active disease, and are more likely to be male, with a long history of heavy smoking. Rheumatoid nodules can occur anywhere, but they are mostly located in the joint bulge and subcutaneous areas of pressure, such as the extension of the forearm and Achilles tendon. The nodules are round or oval in shape, varying in size from a few millimeters to several centimeters in diameter, hard, non-indurated, and symmetrically distributed. They may also involve all organs such as the heart, lungs, pleura, and eyes. The presence of rheumatoid nodules suggests that rheumatoid arthritis is active and requires active treatment. When rheumatoid nodules are present, it is recommended to seek prompt medical attention, follow the doctor’s instructions for further examination, and carry out targeted treatment or therapy under the doctor’s guidance.