Acne refers to acne in medicine, and 50-year-old women always have acne may be caused by polycystic ovary syndrome, clogged pores, and bad cosmetic ingredients. 1. Polycystic Ovary Syndrome (PCOS): a common reproductive endocrine metabolic disease, the etiology of PCOS is still unclear and may be related to genetic and environmental factors. Due to endocrine disorders, the phenomenon of androgen increase can occur, so that the sebaceous glands increase in size, sebum secretion increases, so that the pores are clogged with always long acne. 2. Pore clogging: when the surrounding cell keratinization is abnormal, it can lead to the follicle opening become small, narrow, blocked, sebum can not be discharged normally, can be piled up in the mouth of the follicle, and thus always have acne. 3. Bad cosmetic ingredients: some people use some poor quality or thick skin care cosmetics for a long time, the skin stratum corneum keratinization, can also appear always long acne. In addition, the 50-year-old always long acne can also be seen in other reasons. It is recommended that patients go to the hospital in time, after clarifying the cause of the disease, standardized treatment under the guidance of the doctor.