Pain on the lateral edge of the foot may be caused by physiological factors such as fatigue or pathological factors such as foot deformity, tenosynovitis, rheumatoid arthritis, etc. Common treatments include medication and surgery. 1. Physiological factors: due to long time walking or inappropriate shoes, etc., it can lead to soft tissue fatigue or extrusion, causing pain on the lateral side of the foot, which can be gradually relieved by taking proper rest, soaking the feet in hot water and replacing the appropriate shoes, and there is no need for special treatment. 2. Foot deformity: such as flat foot, pronator teres, valgus foot and other foot deformities, walking too much can also lead to pain on the outside of the foot, rest can relieve the pain, but those with obvious symptoms often need targeted orthopedic treatment. 3. Tenosynovitis: there are tendons distributed on the lateral side of the sole of the foot, and improper posture may cause repeated wear and tear of the tendons to produce aseptic inflammatory reaction, resulting in pain when walking. Non-steroidal drugs such as diclofenac diethylamide latex can be applied externally or oral ibuprofen can be taken to alleviate the pain symptoms, and surgical treatment may be required if necessary. 4. Rheumatoid arthritis: This disease causes synovial membrane hyperplasia and destruction of articular cartilage, which leads to pain in the toe joints and also manifests as pain on the lateral edge of the foot. Treatment drugs include anti-rheumatic drugs such as penicillamine, anti-inflammatory drugs such as meloxicam, etc. Surgical treatment including synovectomy is necessary to stop local inflammation and relieve pain effectively. The symptoms of lateral edge of the foot pain, exclude physiological causes should be promptly to the hospital, so as not to delay the condition.