Pain in the middle of the hand may be caused by overwork, finger trauma, rheumatoid arthritis and other reasons. 1. Over-exertion: patients have excessive hand labor due to work and other reasons, which can cause hand muscle injury and pain in the middle of the hand. 2. Finger trauma: patients due to hand trauma, such as heavy objects hit the fingers, so that the soft tissue damage, may also lead to fracture, thus appearing in the middle of the hand pain phenomenon. 3. Rheumatoid arthritis: Rheumatoid arthritis is a rheumatic immune disease, which may cause morning stiffness, pain, limited joint movement and other symptoms, and patients may also experience pain in the middle of the hand. If the patient has pain in the middle of the hand, it is recommended to go to the hospital in time, diagnosed by a professional doctor, and make reasonable treatment.