Gastric disease intestinal chemosis without medication when the stomach is more comfortable, consider the patient with medication after the occurrence of gastrointestinal adverse reactions, the patient is not sensitive to therapeutic drugs. 1. Gastrointestinal adverse reactions occurring with oral medications: intestinal chemosis generally refers to chronic atrophic gastritis, and most of the patients with intestinal chemosis have Helicobacter pylori infection, which can be treated with anti-Helicobacter pylori quadruple therapy (omeprazole, bismuth potassium citrate, clarithromycin, amoxicillin). Adverse gastrointestinal reactions may occur during treatment with the above medications, causing more discomfort to the patient. 2. Not sensitive to therapeutic drugs: everyone’s sensitivity to drugs and therapeutic effects are different, oral treatment of gastropathy drugs may also appear insensitive to the problem, the patient’s responsiveness to the drug is poor. For patients with gastric disease accompanied by intestinal metaplasia, it is recommended to go to the gastroenterology department of regular hospitals in time when the situation of more comfortable without medication occurs, and choose the next step in the treatment under the guidance of doctors.