Coughing in the middle of the night may be caused by cough variant asthma, cardiac insufficiency, upper respiratory tract infections and so on. 1. Cough variant asthma: the most common cough in the middle of the night is cough variant asthma, which is mainly characterized by irritating cough at night. Examinations such as bronchodilator/exciter test are needed, along with early treatment. 2. Cardiac insufficiency: especially in left heart failure, there may be paroxysmal dyspnea and cough at night. Echocardiography and serum myocardial damage markers should be performed in time for clarification. 3. Upper respiratory tract infections: cough in the middle of the night can also occur, the respiratory tract due to viral or bacterial infections leading to inflammatory response, cough in the middle of the night. Cough in the middle of the night can also be seen in a variety of other reasons, the specific causes need to be examined and clarified, and at the same time, follow the doctor’s instructions for scientific treatment.