Syphilis rash is a typical symptom of stage II syphilis, the rash manifestation lacks specificity, and can be manifested as erythema, papule, pustule, etc.. 1. Pemphigus: typical symptoms of the patient’s proximal limbs or trunk and other parts, the appearance of maroon or rose-colored rash, the appearance of the rash is generally oval or round, and there is discoloration after pressing. 2. Papular: it will appear in the abdomen, genital area, both sides of the trunk and other parts of the patient, manifested as round papules, the color of the papules is usually dark red, slightly higher than the skin. 3. Pustular: this condition is relatively rare, usually grows in the limbs, face and trunk and other parts of the body, manifested as red pustules, and the morphology varies greatly, may be manifested as acne-like, pustular and so on. If the patient has the above symptoms, need to pay attention to, timely medical examination.