Postoperative retroperitoneal lymph node 0.6cm in adrenocortical carcinoma may be normal, or it may be caused by tumor metastasis, which needs further clear diagnosis or anti-tumor treatment. 1. Normal situation: lymph nodes exist in retroperitoneum in physiological situation, usually not more than 1 cm. Therefore, 0.6cm of retroperitoneal lymph nodes after adrenocortical cancer surgery may be a normal physiological phenomenon, and if further examination does not indicate any abnormality, there is no need for excessive anxiety. 2. Tumor metastasis: if there are more retroperitoneal lymph nodes with persistent enlargement, it may be caused by tumor metastasis, which needs to be further diagnosed by pathological biopsy and other methods. After diagnosis, systemic treatment is usually given, including Mitotane monotherapy or the combination of cisplatin, carboplatin, etoposide, doxorubicin, streptozotocin and Mitotane. Patients are advised to seek prompt medical attention to evaluate their condition and target observation or treatment under medical supervision. Drug treatment please strictly follow the doctor’s instructions, do not self-medication.