Elevated thyroglobulin should be considered as a possible cause of Hashimoto’s thyroiditis, Graves’ disease, thyroid adenoma, subacute thyroiditis, thyroid cancer, etc. It should be taken seriously. If the thyroid function is normal, it usually does not matter; if the thyroid function is abnormal, it is necessary to go to the hospital in time for examination and clear diagnosis. Thyroglobulin is a macromolecular glycoprotein secreted by thyroid follicular epithelial cells and is a precursor protein for thyroid hormone synthesis. Thyroglobulin is elevated in many benign and malignant diseases. 1. Benign diseases: Elevated thyroglobulin often indicates the presence of autoimmune diseases such as Hashimoto’s thyroiditis, which need to be diagnosed in combination with other indicators. These benign diseases can be treated in regular hospitals. 2. Malignant diseases: if thyroglobulin is elevated after thyroid cancer surgery, it suggests that there may be tumor recurrence or metastasis, which is more serious. It is necessary to follow the doctor’s advice to choose the appropriate treatment plan. If the thyroglobulin is elevated, you should go to the hospital for further examination in time, so as to clarify the cause of the disease and treat it according to the cause.