Hand cramps during the treatment of membranous nephropathy are usually considered to be caused by hypocalcemia, which requires calcium supplementation treatment. Hypocalcemia is the main cause of hand cramps in patients with membranous nephropathy. The treatment of membranous nephropathy usually requires the application of high-dose glucocorticosteroids in combination with other immunosuppressive drugs, and the long-term application of high-dose hormones can lead to hypocalcemia. Therefore, patients need to improve the serum electrolyte related examination, if it is caused by hypocalcemia, it is necessary to carry out calcium supplementation therapy, more commonly used calcium carbonate D3, etc. At the same time, it is recommended that appropriate sun exposure to promote the absorption of calcium. There may be other reasons for hand cramps during the treatment of membranous nephropathy, so it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.