Large laryngeal nodes in men are generally normal phenomenon, males will have the development of laryngeal nodes during puberty, the better development is manifested as large laryngeal nodes, usually without treatment. Girls with large laryngeal nodes may be due to endocrine diseases, which should be treated in time. 1. Physiological reasons: boys to a certain age will have the development of the laryngeal knot, so it will become larger, part of the body due to thinner or better development, so the laryngeal knot than other people feel more prominent, these cases are generally not accompanied by other symptoms, without special treatment. 2. Female endocrine diseases: The increase of androgen or decrease of estrogen may be caused by ovarian hypoplasia, pituitary tumors, and so on, accompanied by masculinization manifestations such as voice coarsening and hairiness. Usually, the cause of the problem needs to be clarified and treated with medication or surgery. If the laryngeal knot is accompanied by other physical symptoms, you should go to the hospital in time for relevant examinations to clarify the cause of the disease, and under the guidance of the doctor to actively carry out the treatment, usually pay attention to develop good living and dietary habits, to avoid excessive use of the voice. It is recommended that patients should consult a doctor if they feel unwell, and should not be negligent so as not to delay or aggravate their condition.