Symptoms of leukemia that may occur before the end of life include systemic manifestations of infection, bleeding, bone and joint pain, central nervous system leukemia symptoms, and mental abnormalities. 1. Systemic infections: leukemia patients are very susceptible to infections due to impaired immune system, and uncontrollable systemic infections are an important cause of patients’ death. Patients may have high fever, cough and sputum, respiratory failure and other signs of infection before death. 2. Bleeding tendency: leukemia patients with severe thrombocytopenia will have different degrees of bleeding tendency, which can be manifested as nosebleeds, skin petechiae and ecchymosis, etc. Among them, cerebral hemorrhage is the most serious, which can be manifested as cerebral hemorrhage. Among them, brain hemorrhage is the most serious, which can be manifested as severe headache, vomiting, pupil size change, etc. In severe cases, brain hernia can be induced and lead to death. 3. Bone and joint pain: when leukemia cells infiltrate bone and joint, it will cause pain in the corresponding parts, and the pain in the lower part of sternum is common. When the tumor causes acute necrosis of bone marrow, there will be severe bone pain. 4. Central nervous system leukemia symptoms: central nervous system is the most common extramedullary infiltration site of leukemia, which can cause dizziness, headache, convulsion, coma and even death. 5. Mental abnormality: long-term disease torture, persistent severe pain, intracranial leukemia infiltration, cerebral hemorrhage, etc. can cause mental abnormality, such as irritability, delirium, lethargy, coma until death. Patients should be actively treated and resuscitated under the guidance of physicians.