Generally, biologics work for ankylosing spondylitis patients. Ankylosing spondylitis is a chronic inflammatory disease, the cause of which is still unclear, and the onset of which may be related to genetics, autoimmune factors, the environment and so on. The disease cannot be cured and can only be relieved by drugs, exercise and biological agents. Biologics are currently effective drugs for the treatment of ankylosing spondylitis, and treatment in the early stages of ankylosing spondylitis can improve patients’ quality of life and stop the progression of the disease. Currently recommended in at least via 2 non-steroidal anti-inflammatory drugs, such as ibuprofen, celecoxib, etc., in the full dose of treatment for 2 to 4 weeks of poor efficacy of the patient can be used in the use of this class of drugs. Ankylosing spondylitis patients are advised to go to the rheumatology and immunology department of the regular hospital in time, and follow the doctor’s instructions for standardized treatment.