High HDL does not require medication if it is not caused by a disease, but if it is caused by a disease such as hepatitis, medication should be taken according to the condition. HDL is often used as an anti-atherosclerotic factor because it promotes the removal of cholesterol from peripheral tissues and prevents the development of atherosclerosis. The normal reference level of HDL is 1.03~2.07mmol/L. Exceeding 2.07mmol/L is an elevated level, which may be a physiological manifestation, or it may be seen in pathological manifestations, such as chronic hepatitis, cirrhosis, fatty liver and other diseases. If the HDL increase is caused by non-disease, there is no need to take medication to intervene; if it is caused by disease, we should actively treat the primary disease, and take relevant medication under the guidance of the doctor, such as viral hepatitis can be applied to entecavir for antiviral, reduced glutathione for liver protection, and so on. It is recommended to receive standardized diagnosis and treatment if necessary.