Increased ghrelin may be caused by physiological factors such as staying up late, drinking alcohol, pathological factors (liver disease, gallbladder disease, heart disease, etc.), medication factors and so on. 1. Physiological factors: overwork, late night, poor rest, alcohol consumption, strenuous exercise before the examination, etc. can lead to an increase in ALT. 2. Pathologic factors: (1) Liver diseases: for example, autoimmune hepatitis, viral hepatitis, alcoholic liver, fatty liver, cirrhosis, etc., which lead to liver cell damage and cause the increase of alanine aminotransferase. (2) Infectious diseases: for example, viral hepatitis, cholecystitis acute attack can induce ghrelin increase. (3) heart disease: such as myocarditis, myocardial infarction, etc. can trigger the increase of ghrelin. (3) Drug factors: taking antipyretic drugs, such as acetaminophen, anti-tuberculosis drugs, such as isoniazid, rifampicin and so on. This can lead to an increase in the enzyme alanine aminotransferase. If you have a high GLT, it is recommended that you seek medical attention to identify the cause of the problem and follow the doctor’s instructions.