1. Gradual increase in size of palpable lumps on the body surface or superficial areas, such as the breast, skin, mouth or other parts of the body. 2.Persistent abnormal digestion, or a feeling of fullness in the upper abdomen after eating. 3. Discomfort behind the sternum or even choking sensation when swallowing food. 4.Persistent cough with blood in the sputum. 5.Tinnitus, hearing loss, nasal and nasopharyngeal secretions with blood. 6.Irregular bleeding outside the menstrual period or after menopause. 7. Positive fecal occult blood, blood in stool, hematuria. 8.Long-standing ulcers. 9.Moles and warts that increase in size, deepen in color, lose hair, itch, and break down within a short period of time. 10.Unexplained weight loss.