Generalized pain may be a sign of rheumatic immune diseases such as gout, trauma, malignant tumors and other diseases. 1. Gout: Gout is a disease in which uric acid crystals are deposited in the joints due to high uric acid level, and the main clinical manifestation is sudden pain in one or more joints. It can be relieved by itself in the early stage, but if not treated actively, it can cause joint deformity in serious cases. 2. Trauma: Multiple traumatic injuries such as large soft tissue contusion or fracture can lead to generalized pain, which can be relieved by local medication or surgical treatment. High-intensity physical exercise or labor can also lead to generalized pain. 3. Malignant tumors: patients with malignant bone tumors will experience generalized pain in the late stage of the disease. Due to the multiple metastasis of bone tumors in the late stage of the disease, all parts of the body may experience symptoms of discomfort. When patients have obvious discomfort, they should go to the hospital immediately.