High rheumatoid factor is common in normal people as well as in rheumatoid immune diseases and infectious diseases, and may affect life expectancy if the disease is severe, but in normal people, high rheumatoid factor alone does not usually affect life expectancy. Rheumatoid factor is a type of antibody, which is an autoantibody produced against the antigenic component of the Fc fragment of IgG antibody that has been denatured. Elevated rheumatoid factor can be seen in some elderly people; in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus; in infectious diseases such as bacterial endocarditis and tuberculosis; and in diffuse interstitial pulmonary fibrosis, tuberculosis, and macroglobulinemia. Therefore, whether or not it affects life expectancy has a great deal to do with whether or not the disease is combined with the disease and the severity of the disease. If it is a normal physiological elevation, it generally does not affect life expectancy, but if it is a patient with a chronic disease, it may affect life expectancy to a certain extent depending on the severity of the disease and the treatment situation. When the rheumatoid factor is elevated, it is recommended that the patient should not be too nervous, and should consult a doctor in time to comprehensively determine the specific cause of the disease and actively treat it.