The big difference between two liver function test results may be caused by physiological factors, or it may be caused by the progress or improvement of the disease, physiological factors do not need special treatment, the progress or improvement of the disease needs to be targeted treatment under the guidance of the doctor. If you do not stop taking drugs that affect liver function tests or do not keep fasting before the liver function test, but keep fasting or stop taking drugs that affect the liver, the difference between the two liver function test results may be big, which is usually caused by physiological factors, and does not need any special treatment in this case. In addition, liver function abnormalities can be seen in cirrhosis, alcoholic hepatitis and other diseases, if the disease improves after standardized treatment, there will be a big difference between the two results, and the latter will be better than the previous one, such cases can continue to follow the doctor’s instructions to use medication can be. However, if the disease progresses, such as when hepatitis B progresses to cirrhosis, it will also cause a big difference between the two liver function test results, and the latter will be more serious than the former, in such cases, you need to adjust the treatment program under the guidance of the doctor, such as when hepatitis B develops into cirrhosis, you need to use liver-protecting drugs, such as reduced glutathione, adenosylmethionine and so on. If there is a big difference between the results of two liver function tests, you can go to the hospital, consult a professional doctor and ask the doctor to make a judgment.