Membranous nephropathy stage I refers to glomerular basement membrane without obvious thickening, extensive “fusion” of pedicles, and small dense deposits under the epithelial cells on the outer side of the glomerular basement membrane, which is usually more serious and needs timely treatment.
The basic treatment of membranous nephropathy includes salt restriction, rest and moderate exercise, and blood pressure control. Angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor antagonists (ARB) should be used to reduce urinary protein only if the patient has no contraindications.
The severity of membranous nephropathy depends not only on the staging, but also on the combination of the patient’s clinical manifestations. The prognosis of patients with massive proteinuria, severe hypertension, renal impairment or hormonal resistance and serious complications is poor.
The disease is prone to thromboembolism, and the incidence of renal vein thrombosis can be as high as 40%~50%. If there is sudden low back pain or rib and abdominal pain, deep vein thrombosis should be alerted.
Patients with membranous nephropathy stage I should go to the hospital in time and be treated under the guidance of specialized physicians.