There is no authoritative data to show what is the life expectancy of squamous carcinoma of the floor of mouth, but research shows that the 5-year cure rate is generally around 60%. Squamous carcinoma of the floor of mouth usually occurs on both sides of tongue tie, and the disease can cause localized mucous membrane ulcers or lumps, and when the disease further progresses, it will lead to symptoms such as loosening or falling off of the lower front teeth and localized lymph node enlargement. For the life expectancy of patients with squamous carcinoma of the floor of mouth, there is no authoritative data reported for the time being, but usually the 5-year cure rate is around 60%. If the disease is actively treated in the early stage, the cure rate can be up to 80%. For patients with squamous carcinoma of the floor of mouth, apart from the stage affecting the life expectancy of patients, the physical quality, patient’s age and treatment effect will also affect the life expectancy. The better the physical quality, the younger the patient is and the better the treatment effect, the better the prognosis may be. Otherwise, the prognosis is relatively poor. It is recommended that patients with squamous carcinoma of the floor of the mouth should actively cooperate with doctors to take treatment measures after diagnosis of the disease, pay attention to adjusting the mentality in daily life and ensure balanced intake of nutrients.