Blisters on the soles of the feet are a common occurrence in everyday life and can be caused by a number of reasons. The most common clinical causes are the following: 1. Blisters from friction. The soles of the feet are a special area for wearing shoes or walking, and blisters can appear if the skin is repeatedly rubbed. This blister is a tissue fluid that does not require special treatment and will subside on its own. 2. fungal infections, patients with tinea pedis usually have erythema, papules, blisters and severe itching that can be treated with topical application of antifungal creams or oral administration of antifungal drugs. 3. patients with eczema or allergic dermatitis also have blisters and inflammatory rashes.