Hookworm larvae invading human skin can cause hookworm dermatitis, and small red papules can appear on the local skin. Hookworm dermatitis is mainly infectious, and patients with hookworm disease are the main source of infection. Skin contact with contaminated soil is the main route of infection, eating contaminated food, vegetables, etc. is also a route of infection. Hookworm dermatitis is widely distributed in China, and its infection rate is higher in the south than in the north, especially in the areas south of the Huaihe River and the Yellow River, higher in rural areas than in cities, higher in adults than in children, and the older the children, the higher the infection rate. The pathogenesis of hookworm dermatitis: dermatitis caused by hookworm larvae, the filarial larvae invade the skin a few minutes to 1h, the local skin appears red papules, 1 to 2d blistering, congestion, edema and cellular infiltration of inflammatory reactions. After 24h of infection, most of the larvae remain in the dermis and subcutaneous tissues, and then reach the lungs via lymphatic vessels or microvessels. When the larvae invade the skin, there is a local itchy rash and protruding papules or small herpes. Scratching can cause secondary infection and local lymph nodes can be enlarged. The skin where the larvae invade feels itchy and burns, followed by small bleeding spots, papules or small herpes, commonly known as “fecal lump”, “fecal poison” and “fecal pimple”. With the migration of the hook larvae in the human body, itchy throat and cough often appear 3 to 5 days after infection, and in severe cases, even violent dry cough or asthma attack. The adult worms parasitize in the small intestine, disturbing the spleen and stomach qi, sucking and consuming human blood, resulting in symptoms of gastrointestinal disorders such as upper abdominal discomfort and vague pain, hyperphagia but reduced labor force, heterophilia for raw rice and tea, and even dirt and shredded paper. In severe cases, symptoms of deficiency of qi and blood such as palpitation and shortness of breath, weakness of limbs, dizziness and tinnitus, swelling of face and feet, yellowish face, pale lips and tongue, and weak pulse. The clinical symptoms of hookworm disease vary in severity and are related to the type, number and duration of hookworm infection and the individual’s nutritional and immune status. Mild cases may have no obvious symptoms. Anemia is usually predominant. The vast majority are asymptomatic hookworm infections.